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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTPN6 All Species: 23.94
Human Site: Y536 Identified Species: 47.88
UniProt: P29350 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P29350 NP_002822.2 595 67561 Y536 Q K G Q E S E Y G N I T Y P P
Chimpanzee Pan troglodytes XP_001163468 596 67703 Y537 Q K G Q E S E Y G N I T Y P P
Rhesus Macaque Macaca mulatta XP_001110915 597 67615 Y538 Q K G Q E S E Y G N I T Y P P
Dog Lupus familis XP_543844 595 67669 Y536 Q K G R E S E Y G N I T Y P L
Cat Felis silvestris
Mouse Mus musculus P29351 595 67540 Y536 Q K G Q E S E Y G N I T Y P P
Rat Rattus norvegicus P81718 613 69560 Y538 Q R G Q E S E Y G N I T Y P P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519010 556 61792 H498 Q Y L S W P D H G V P S E P G
Chicken Gallus gallus Q90687 593 67964 K534 R R I E E E Q K S K R K G H E
Frog Xenopus laevis NP_001085766 594 68095 M534 R P L E E E Q M G K L K E H E
Zebra Danio Brachydanio rerio NP_956254 589 66986 M530 K V T R R A I M E T E T E Y G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P29349 845 92957 Y666 S L Q V G R E Y T N I K Y T G
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784121 533 60826 H475 Y I N T K R A H Y E V Q Q H H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.9 97.8 96.1 N.A. 94.4 91 N.A. 68 54.2 58.3 64.7 N.A. 33.8 N.A. N.A. 43.3
Protein Similarity: 100 98.8 98.4 97.9 N.A. 98.1 94.9 N.A. 72.9 70.7 72 78.4 N.A. 46.9 N.A. N.A. 60.8
P-Site Identity: 100 100 100 86.6 N.A. 100 93.3 N.A. 20 6.6 13.3 6.6 N.A. 33.3 N.A. N.A. 0
P-Site Similarity: 100 100 100 93.3 N.A. 100 100 N.A. 40 33.3 40 26.6 N.A. 33.3 N.A. N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 9 9 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 17 67 17 59 0 9 9 9 0 25 0 17 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 50 0 9 0 0 0 67 0 0 0 9 0 25 % G
% His: 0 0 0 0 0 0 0 17 0 0 0 0 0 25 9 % H
% Ile: 0 9 9 0 0 0 9 0 0 0 59 0 0 0 0 % I
% Lys: 9 42 0 0 9 0 0 9 0 17 0 25 0 0 0 % K
% Leu: 0 9 17 0 0 0 0 0 0 0 9 0 0 0 9 % L
% Met: 0 0 0 0 0 0 0 17 0 0 0 0 0 0 0 % M
% Asn: 0 0 9 0 0 0 0 0 0 59 0 0 0 0 0 % N
% Pro: 0 9 0 0 0 9 0 0 0 0 9 0 0 59 42 % P
% Gln: 59 0 9 42 0 0 17 0 0 0 0 9 9 0 0 % Q
% Arg: 17 17 0 17 9 17 0 0 0 0 9 0 0 0 0 % R
% Ser: 9 0 0 9 0 50 0 0 9 0 0 9 0 0 0 % S
% Thr: 0 0 9 9 0 0 0 0 9 9 0 59 0 9 0 % T
% Val: 0 9 0 9 0 0 0 0 0 9 9 0 0 0 0 % V
% Trp: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 9 0 0 0 0 0 59 9 0 0 0 59 9 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _